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A recent rewarded proposal by STW perspective is “Understanding Processes Using Operando Nanoscopy (UPON)” UPON is a STW perspective program with 4 projects on producing nano reactors for TEM and SEM and 4 project on using these nano reactors for in-situ TEM.

Conventional SNP typing methods are typically time consuming and expensive, requiring several probe based assays to be multiplexed together or the use of DNA microarrays. HRM is more cost effective and reduces the need to design multiple pairs of primers and the need to purchase expensive probes. The HRM method has been successfully used to detect a single G to A substitution in the gene Vssc (Voltage Sensitive Sodium Channel) which confers resistance to the acaricide permethrin in Scabies mite. This mutation results in a coding change in the protein (G1535D). The analysis of scabies mites collected from suspected permethrin susceptible and tolerant populations by HRM showed distinct melting profiles. The amplicons from the sensitive mites were observed to have a higher melting temperature relative to the tolerant mites, as expected from the higher thermostability of the GC base pair [3]

The system will be designed to have both “read-out” and “write-in” capabilities. It will be able to record neural activity, helping to deepen scientists’ understanding of how the brain processes stimuli from the outside world. It will also have the capability to stimulate neural activity through tiny electrical pulses, a function researchers hope to eventually use in human clinical research aimed at restoring brain function lost to injury or disease.

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The system will be designed to have both “read-out” and “write-in” capabilities. It will be able to record neural activity, helping to deepen scientists’ understanding of how the brain processes stimuli from the outside world. It will also have the capability to stimulate neural activity through tiny electrical pulses, a function researchers hope to eventually use in human clinical research aimed at restoring brain function lost to injury or disease.